🧸 Section: Pediatrics & Internal Medicine and Clinical Cases & Pediatrics

Second Place:

Name: Mishra Sarita, Sagar Saini University: Poltava State Medical University (Student) Topic: Early Diagnosis and Management of Neonatal Sepsis

Neonatal sepsis remains a leading cause of newborn mortality, requiring rapid diagnosis and timely intervention. Mishra Sarita and Sagar Saini’s research provides a comprehensive analysis of early diagnostic strategies and effective management protocols to improve neonatal outcomes.

✅ Key Insights:

• Early Diagnosis: Utilizes advanced biomarkers (CRP, Procalcitonin, Presepsin) and molecular diagnostics (PCR, Next-Generation Sequencing) for rapid detection.

• Management: Emphasizes empiric antibiotic therapy, supportive care, and adjunctive treatments like IVIG and probiotics.

• Antibiotic Stewardship: Highlights the importance of de-escalating therapy and using rapid diagnostic tools to combat antimicrobial resistance.

• Future Directions: Explores cutting-edge innovations, including AI-driven sepsis prediction, point-of-care diagnostics, and microbiome research.

✨ In recognition of their outstanding contribution to pediatric medicine,

#MedicalVisionary3 #MedUpgrade #Pediatrics #NeonatalSepsis #EarlyDiagnosis #AntibioticStewardship #NeonatalCare #FutureofMedicine

THIRD Place:

Name: Joshi Ravi Kant, Biswas Milee University: Poltava State Medical University (Student) Topic: Impact of SGLT2 Inhibitors Beyond Diabetes: A Cardioprotective Revolution

Sodium-glucose cotransporter-2 (SGLT2) inhibitors, initially developed for type 2 diabetes mellitus (T2DM), have emerged as a groundbreaking therapy with cardiovascular (CV) and renal benefits across both diabetic and non-diabetic populations. Joshi Ravi Kant and Biswas Milee’s research explores the mechanistic insights, key clinical trials, and the evolving role of SGLT2 inhibitors in modern internal medicine.

✅ Key Insights:

• Mechanisms of Cardioprotection:

  • Diuresis & Natriuresis: Reduces plasma volume, preload, and cardiac stress.

  • Metabolic Shifts: Enhances ketone metabolism, improving myocardial energy efficiency.

  • Anti-Inflammatory Effects: Reduces oxidative stress and myocardial fibrosis.

• Clinical Evidence:

  • EMPA-REG OUTCOME (2015): 38% reduction in CV mortality with empagliflozin.

  • DAPA-HF (2019): 26% reduction in heart failure (HF) hospitalizations regardless of diabetes status.

  • EMPEROR-Reduced (2020): Improved HF outcomes and slowed CKD progression in both diabetic and non-diabetic patients.

• Applications Beyond Diabetes:

  • Heart Failure: Effective in HFrEF management, even for non-diabetics.

  • Chronic Kidney Disease: Slows CKD progression and reduces renal failure risk.

  • Hypertension: Supports blood pressure reduction and improved vascular health.

• Safety Considerations:

  • Common: Urinary tract infections, dehydration, hypotension.

  • Serious: Euglycemic diabetic ketoacidosis (euDKA), acute kidney injury, and amputation risks (CANVAS trial).

🌟 Future Directions:

• Expanding Indications: Investigate effects in HFpEF and CKD for non-diabetic populations.

• Combination Therapies: Explore synergy with ARNIs and MRAs for comprehensive HF treatment.

• Mechanistic Insights: Deepen understanding of pathways like TGF-β modulation and mitochondrial function.

#MedicalVisionary3 #MedUpgrade #InternalMedicine #SGLT2Inhibitors #HeartFailure #ChronicKidneyDisease #CardiometabolicInnovation

THIRD Place:

Names: Sehgal Simran, Joshi Ravi Kant Universities: Jalal-Abad State University, Kyrgyzstan & Poltava State Medical University, Ukraine Topic: The Impact of Early Skin-to-Skin Contact on Neonatal Health Outcomes: A Review and Future Perspectives

Skin-to-skin contact (SSC), also known as Kangaroo Mother Care (KMC), has emerged as a fundamental neonatal intervention with physiological, psychological, and developmental benefits. This research by Sehgal Simran and Joshi Ravi Kant explores the evidence-based impact of early SSC on newborn health, highlighting its role in thermoregulation, cardiovascular stability, breastfeeding success, and maternal bonding.

✅ Key Findings:

• Physiological Benefits:

  • 🔥 Thermoregulation: SSC helps maintain optimal neonatal temperature, reducing hypothermia risk.

  • 💓 Cardiovascular Stability: Improves heart rate and oxygen saturation, reducing apnea and bradycardia in preterm infants.

• Psychological & Developmental Impact:

  • 🧠 Stress Reduction: Lowers cortisol levels, reducing neonatal distress during procedures.

  • 🤱 Maternal Bonding: Enhances oxytocin release, lowering postnatal depression rates.

• Breastfeeding & Nutritional Outcomes:

  • 🍼 Breast Crawl Reflex: Newborns latch onto the breast without assistance.

  • 📈 Higher Success Rates: Infants receiving SSC have a 64% increased likelihood of exclusive breastfeeding at 3 months.

• Special Considerations in Preterm Infants:

  • 🏥 Neurodevelopmental Benefits: SSC reduces the risk of necrotizing enterocolitis (NEC) and neonatal mortality by 36%.

🌍 Challenges in Implementation:

• Cultural Barriers: Traditional postnatal customs may limit SSC adoption.

• NICU Resource Limitations: Lack of trained staff and infrastructure hinders routine SSC in hospitals.

• Parental Anxiety: Misconceptions about SSC in fragile preterm infants require education & reassurance.

🚀 Future Perspectives & Research Directions:

• NICU Integration: Develop standardized SSC protocols for premature infants.

• Technology & SSC: Explore wearable monitoring devices for real-time vital tracking.

• Policy & Advocacy: Promote global SSC guidelines through public health campaigns and healthcare reforms.

Their work highlights SSC as a life-saving intervention—advocating for its universal adoption in healthcare policies and neonatal care practices.

#PediatricsExcellence #MedUpgrade #NeonatalHealth #SkinToSkinContact #KangarooMotherCare